Repairing skull defects in children with nano-hap/collagen composites: A clinical report of thirteen cases

doi:10.18679/CN11-6030/R.2016.005

Translational Neuroscience and Clinics

2016, Vol. 2

Issue (1): 31-37 doi: 10.18679/CN11-6030/R.2016.005

Original Articles

Repairing skull defects in children with nano-hap/collagen composites: A clinical report of thirteen cases

Tuoyu Chen¹, Yuqi Zhang¹, Huancong Zuo¹, Yapeng Zhao³, Chaoqiang Xue¹, Bin Luo¹, Qinglin Zhang¹, Jin Zhu¹, Xiumei Wang², Fuzhai Cui²

1 Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100040, China;
2 School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China;
3 The Medical Center, Tsinghua University, Beijing 100084, China

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Abstract Objective: To evaluate the clinical results of repairing skull defects with biomimetic bone (nano-hap/collagen composites, NHACs) in children. Methods: Thirteen children with skull defects were treated with NHACs in our hospital. The NHACs molded with the help of a 3D printer were used in the operations. Results: All 13 operations were successful, and patients recovered without infection. Only one patient suffered from subcutaneous hydrops post-operation. The implanted NHACs remained fixed well after 1 year, and their CT HU values raised gradually. Skull shapes of children developed normally. Recovery of neurological and cognitive function was significant. Conclusions: NHAC, chosen to repair skull defects in children, can coexist with normal skull and reduce the negative effects on growth and development. NHAC could be a good choice for children with skull defects.

Key words： cranioplasty children biomimetic bone 3D printing

Received: 05 January 2016 Published: 31 March 2016

Corresponding Authors: Yuqi Zhang, E-mail: yuqi9597@sina.com E-mail: yuqi9597@sina.com


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	Tuoyu Chen
	Yuqi Zhang
	Huancong Zuo
	Yapeng Zhao
	Chaoqiang Xue
	Bin Luo
	Qinglin Zhang
	Jin Zhu
	Xiumei Wang
	Fuzhai Cui

Cite this article:

Tuoyu Chen, Yuqi Zhang, Huancong Zuo, Yapeng Zhao, Chaoqiang Xue, Bin Luo, Qinglin Zhang, Jin Zhu, Xiumei Wang, Fuzhai Cui. Repairing skull defects in children with nano-hap/collagen composites: A clinical report of thirteen cases. Translational Neuroscience and Clinics, 2016, 2(1): 31-37.

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http://tnc.tsinghuajournals.com/10.18679/CN11-6030/R.2016.005 OR http://tnc.tsinghuajournals.com/Y2016/V2/I1/31

Table 1 Summary of the basic clinical features

Figure 1a The preoperative computer reconstruction. Figure 1b Biomimetic bone is suitably fixed by a 10/0 thread, with space for temporal muscle roots reserved. Figure 1(c–d) Postoperative cranial volume rendering technique (VRT) reconstruction reveals suitable head shape, good radian, and moderate thickness. Figure 1e Postoperative computed tomography (CT) of the skull bone window reveals density of the biomimetic bone between the cancellous bone and compact bone

Figure 2a Postoperative head X-ray image of 1 case reveals satisfactory fixation of the biomimetic bone, good radian, connected to the coronal suture without crack. Figure 2b Postoperative head X-ray image of the same case 1 year later shows density of the biomimetic bone close to the normal bone, but visible cracks can be observed, consistent with child’s normal skull development.

Figures 3(a–f) Different cases of cranioplasty show well appearances in postoperative cranial VRT reconstruction. Figures 3c–3f show the movement of temporal muscle was free.

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[1]	Qingsheng Yu, Lin Chen, Zhiye Qiu, Yuqi Zhang, Tianxi Song, Fuzhai Cui. Skull repair materials applied in cranioplasty: History and progress[J]. Translational Neuroscience and Clinics, 2017, 3(1): 48-57.

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