Factors influencing the effects of repetitive transcranial magnetic stimulation in Parkinson's disease
Na Ye1, Tao Feng2
1. Fifth College of Clinical Medicine, Capital Medical University, Beijing 100050, China;
2. Department of Neurodegenerative Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
Factors influencing the effects of repetitive transcranial magnetic stimulation in Parkinson's disease
Na Ye1, Tao Feng2
1. Fifth College of Clinical Medicine, Capital Medical University, Beijing 100050, China;
2. Department of Neurodegenerative Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
摘要 Barker first used transcranial magnetic stimulation in 1985 in human brain function research. Since then, it has gradually been developed into a secure and non-invasive treatment method for neurological diseases. In 1994, Pascual Leone first used it for the treatment of Parkinson's disease (PD) and observed an improvement in the motor symptoms of most of the patients. Recent studies have confirmed that both motor and non-motor symptoms of patients with PD could be improved through biochemical, electrophysiological, and functional magnetic resonance imaging analysis. Different therapeutic applications can be achieved by adjusting the stimulation parameters. Physical factors affecting the therapeutic effect include the shape and size of the coil, array orientation, materials and intensity, frequency of stimulus, etc.; the biological factors include stimulating targets, baseline, circadian rhythms, cerebral cortex thickness, and so on. This paper will review these factors and provide a reference for future research.
Abstract: Barker first used transcranial magnetic stimulation in 1985 in human brain function research. Since then, it has gradually been developed into a secure and non-invasive treatment method for neurological diseases. In 1994, Pascual Leone first used it for the treatment of Parkinson's disease (PD) and observed an improvement in the motor symptoms of most of the patients. Recent studies have confirmed that both motor and non-motor symptoms of patients with PD could be improved through biochemical, electrophysiological, and functional magnetic resonance imaging analysis. Different therapeutic applications can be achieved by adjusting the stimulation parameters. Physical factors affecting the therapeutic effect include the shape and size of the coil, array orientation, materials and intensity, frequency of stimulus, etc.; the biological factors include stimulating targets, baseline, circadian rhythms, cerebral cortex thickness, and so on. This paper will review these factors and provide a reference for future research.
通讯作者:
Tao Feng,E-mail:happyft@sina.com
E-mail: happyft@sina.com
引用本文:
Na Ye, Tao Feng. Factors influencing the effects of repetitive transcranial magnetic stimulation in Parkinson's disease[J]. 临床转化神经科学, 2016, 2(4): 252-259.
Na Ye, Tao Feng. Factors influencing the effects of repetitive transcranial magnetic stimulation in Parkinson's disease. Translational Neuroscience and Clinics, 2016, 2(4): 252-259.
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