Please wait a minute...
Translational Neuroscience and Clinics  2017, Vol. 3 Issue (1): 28-34    doi: 10.18679/CN11-6030/R.2017.004
Original Articles     
Resection of intramedullary spinal cord tumor under awake anesthesia: A novel approach to minimize postoperative motor deficits
Ahsan Ali Khan1, Lukui Chen1, Xiaoyuan Guo1, Hong Wang1, Guojian Wu1, Jun Kong1, Ning Yin2
1 Department of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing 210009, China;
2 Department of Anaesthesia, Zhongda Hospital, Southeast University, Nanjing 210009, China
Download: PDF (3337 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  Objective: To observe advantages and disadvantages of the resection of intramedullary spinal cord tumor under awake anesthesia.
Methods: Two patients with intramedullary spinal cord tumor underwent resection under awake anesthesia and followed up post-operatibely for any motor deficits.
Results: Patients who underwent tumor resection under awake (AAA) anesthesia combined with intraoperative NPM had no motor deficits postoperatively. More accurate and nondelayed responses were observed in the awake cycle of anesthesia and helped guide surgery, thus avoiding injuries to the spinal cord.
Conclusion: Intramedullary spinal cord tumors are not common, but only gross total resection (GTR) can provide complete remission of symptoms and progression-free survival. However, GTR sometimes results in motor function deficits postoperatively, particularly when the cervical cord is involved, and especially if surgery is done under general anesthesia with intraoperative neurophysiological monitoring (NPM) alone, because of delayed sensory evoked potential and motor evoked potential responses. We present two cases that underwent GTR of cervical intramedullary spinal cord tumors under an asleep-awake-asleep (AAA) cycle of anesthesia, combined with intraoperative NPM in which no post-operative motor deficits were observed on 6-months hs follow up.


Key wordsintramedullary      spinal cord      tumor      awake      neurophysiological monitoring     
Received: 22 December 2016      Published: 31 March 2017
Cite this article:

Ahsan Ali Khan, Lukui Chen, Xiaoyuan Guo, Hong Wang, Guojian Wu, Jun Kong, Ning Yin. Resection of intramedullary spinal cord tumor under awake anesthesia: A novel approach to minimize postoperative motor deficits. Translational Neuroscience and Clinics, 2017, 3(1): 28-34.

URL:

http://tnc.tsinghuajournals.com/10.18679/CN11-6030/R.2017.004     OR     http://tnc.tsinghuajournals.com/Y2017/V3/I1/28

 
 
 
 
 
[1]   Klekamp J, Samii M. Surgery of Spinal Tumors. Berlin Heidelberg: Springer, 2007.
[2]   McCormick PC, Stein BM. Intramedullary tumors in adults. Neurosurg Clin N Am 1990, 1(3): 609-630.
[3]   Wang ZY, Sun JJ, Xie JC, Li ZD, Ma CC, Liu B, Chen XD, Liao HI, Yu T, Zhang J. Comparative analysis on the diagnosis and treatments of multisegment intramedullary spinal cord tumors between the different age groups. Neurosurg Rev 2012, 35(1): 85-93.
[4]   Kim SH, Bak KH, Kim DW, Kang TH. Primary intramedullary spinal sarcoma: A case report and review of the current literatures. J Korean Neurosurg Soc 2010, 48(5): 448-451.
[5]   McGirt MJ, Goldstein IM, Chaichana KL, Tobias ME, Kothbauer KF, Jallo GI. Extent of surgical resection of malignant astrocytomas of the spinal cord: Outcome analysis of 35 patients. Neurosurgery 2008, 63(1): 55-61.
[6]   Beneš VIII, Barsa P, Beneš VJr, Suchomel P. Prognostic factors in intramedullary astrocytomas: A literature review. Eur Spine J 2009, 18(10): 1397-1422.
[7]   Garcés-Ambrossi GL, McGirt MJ, Mehta VA,Sciubba DM, Witham TF, Bydon A, Wolinksy JP, Jallo GI, Gokaslan ZL. Factors associated with progression-free survival and longterm neurological outcome after resection of intramedullary spinal cord tumors: Analysis of 101 consecutive cases. J Neurosurg Spine 2009,11(5): 591-599.
[8]   Chi JH, Parsa AT. Intramedullary spinal cord metastasis: Clinical management and surgical considerations. Neurosurg Clin N Am 2006, 17(1): 45-50.
[9]   Abdel-Wahab M, Etuk B, Palermo J, Shirato H, Kresl J, Yapicier O, Walker G, Scheithauer BW, Shaw E, Lee C, et al. Spinal cord gliomas: A multi-institutional retrospective analysis. Int J Radiat Oncol Biol Phys 2006, 64(4): 1060-1071.
[10]   Blanshard HJ, Chung F, Manninen PH, Taylor MD, Bernstein M. Awake craniotomy for removal of intracranial tumor: Considerations for early discharge. Anesth Analg 2001, 92(1): 89-94.
[11]   Pereira LCM, Oliveira KM, L'Abbate GL, Sugai R, Ferreira JA, da Motta LA. Outcome of fully awake craniotomy for lesions near the eloquent cortex: Analysis of a prospective surgical series of 79 supratentorial primary brain tumors with long follow-up. Acta Neurochir(Wien) 2009, 151(10): 1215-1230.
[12]   De Benedictis A, Moritz-Gasser S, Duffau H. Awake mapping optimizes the extent of resection for low-grade gliomas in eloquent areas. Neurosurgery 2010, 66(6): 1074-1084.
[13]   Chacko AG, Thomas SG, Babu KS, Daniel RT, Chacko G, Prabhu K, Cherian V, Korula G. Awake craniotomy and electrophysiological mapping for eloquent area tumours. Clin Neurol Neurosurg 2013, 115(3): 329-334.
[14]   de Amorim RLO, de Almeida AN, de Aguiar PHP, Fonoff ET, Itshak S, Fuentes D, Teixeira MJ. Cortical stimulation of language fields under local anesthesia: Optimizing removal of brain lesions adjacent to speech areas. Arq Neuropsiquiatr 2008, 66(3A): 534-538.
[15]   Hoshimaru M, Koyama T, Hashimoto N, Kikuchi H. Results of microsurgical treatment for intramedullary spinal cord ependymomas: Analysis of 36 cases. Neurosurgery 1999, 44(2): 264-269.
[16]   Jallo GI, Freed D, Epstein F. Intramedullary spinal cord tumors in children. Childs Nerv Syst 2003, 19(9): 641-649.
[17]   Jallo GI, Kothbauer KF, Epstein FJ. Intrinsic spinal cord tumor resection. Neurosurgery 2001, 49(5): 1124-1128.
[18]   Morota N, Deletis V, Constantini S, Kofler M, Cohen H, Epstein FJ. The role of motor evoked potentials during surgery for intramedullary spinal cord tumors. Neurosurgery 1997, 41(6): 1327-1336.
[19]   Matsuyama Y, Sakai Y, Katayama Y, Imagama S, Ito Z, Wakao N, Sato K, Kamiya M, Yukawa Y, Kanemura T, et al. Surgical results of intramedullary spinal cord tumor with spinal cord monitoring to guide extent of resection. J Neurosurg Spine 2009, 10(5): 404-413.
[20]   Cristante L, Herrmann HD. Surgical management of intramedullary spinal cord tumors: Functional outcome and sources of morbidity. Neurosurgery 1994, 35(1): 69-76.
[21]   Sandalcioglu IE, Hunold A, Müller O, Bassiouni H, Stolke D, Asgari S. Spinal meningiomas: Critical review of 131 surgically treated patients. Eur Spine J 2008, 17(8): 1035-1041.
[22]   Schwartz TH, McCormick PC. Intramedullary ependymomas: Clinical presentation, surgical treatment strategies and prognosis. J Neuro-Oncol 2000, 47(3): 211-218.
[23]   Yang SY, Yang XY, Hong GL. Surgical treatment of one hundred seventy-four intramedullary spinal cord tumors. Spine 2009, 34(24): 2705-2710.
[24]   Boström A, Kanther NC, Grote A, Boström J. Management and outcome in adult intramedullary spinal cord tumours: A 20-year single institution experience. BMC Res Notes 2014, 7: 908.
[1] Liang Zhang, Zhifeng Zhang, Jifeng Shang, Wenqing Jia, Jun Yang, Yulun Xu. Spinal capillary hemangioma: Report of five surgical cases and literature review[J]. Translational Neuroscience and Clinics, 2017, 3(4): 196-203.
[2] Peihai Zhang, Zhenxing Sun, Dan Yuan, Yaxing Sun, Zhanquan Zhang, James Wang, Yi Guo, Guoqin Wang, Dongkang Liu, Peng Chen, Linkai Jing, Feng Yang, Huifang Zhang, Wei Shi, Guihuai Wang. Surgical resection of a cervical intramedullary schwannoma:A case report and literature review[J]. Translational Neuroscience and Clinics, 2017, 3(3): 151-158.
[3] Zhenxing Sun, Dan Yuan, Yaxing Sun, Zhanquan Zhang, James Wang, Yi Guo, Guoqin Wang, Dongkang Liu, Peng Chen, Linkai Jing, Feng Yang, Peihai Zhang, Huifang Zhang, Youtu Wu, Wei Shi, Guihuai Wang. Fluorescein sodium use during spinal ependymoma resection[J]. Translational Neuroscience and Clinics, 2017, 3(3): 123-134.
[4] Linkai Jing, Zhenxing Sun, Yi Guo, Youtu Wu, James Wang, Guihuai Wang. Posterior mediastinal ganglioneuroma:A case report and literature review[J]. Translational Neuroscience and Clinics, 2017, 3(3): 147-150.
[5] Xinmin Wu, Hongquan Yu, Gang Zhao, Le Wang, Yang Liu, Yunqian Li. Intrasellar cavernous hemangioma:A case report and literature review[J]. Translational Neuroscience and Clinics, 2017, 3(2): 111-115.
[6] Yong Hu. Neuroimaging techniques and their application in the spinal cord[J]. Translational Neuroscience and Clinics, 2016, 2(4): 211-214.
[7] Meiqing Lou, Yaodong Zhao. A "logarithmic spiral" in the brain: Images of an intracranial dermoid cyst[J]. Translational Neuroscience and Clinics, 2016, 2(4): 241-243.
[8] Yapeng Zhao, Hongyu Duan, Qinghui Zhang, Bingxin Shi, Hui Liang, Yuqi Zhang. Malignant transformation and treatment of cystic mixed germ cell tumor[J]. Translational Neuroscience and Clinics, 2016, 2(1): 25-30.
[9] Dajue Wang. Why does a little mean a lot when you have nothing? A brief review of cell therapy strategies for spinal cord injury[J]. Translational Neuroscience and Clinics, 2015, 1(2): 102-109.