Translational Neuroscience and Clinics

Nerve grafting is a new treatment option for stroke patients

Shaocheng Zhang

2017, 3(4): 185-187. doi:10.18679/CN11-6030/R.2017.027

Abstract ( 641 )

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Recently, New England Journal of Medicine published an article by the famous hand surgery specialists, Yudong Gu. The important medical achievements of Gu's team include transposition of C7 nerve root of the unaffected side on the upper limbs in stroke hemiplegia, changing the brain central dominance region, and rebuilding the function of hands with spastic paralysis. These achievements are admirable because worldwide medical problems, such as stroke sequela hemiplegia, require long-term arduous...

Using nerve segment insert grafting to reconstruct neural pathways of brain-derived paralysis

Wenbin Ding, Shaocheng Zhang, Zhuo Wang, Lin Chen, Chuansen Zhang, Ping Huang, Shunfa Liu, Laiqing Sun, Yuhai Ma, Jun Yang, Fei Huang, Chengjing Xue, Yanxue Zhong, Lei Yin, Yongtai Pan, Dajiang Wu

2017, 3(4): 188-195. doi:10.18679/CN11-6030/R.2017.028

Abstract ( 606 )

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Since 1992, task groups have used free nerve auto grafts to bridge partially transected nerves from the dominant area of the normal cerebral cortex to nerves that innervate spastic muscles from a diseased cerebral cortex, using transplanting sutures to alleviate the muscle spasm of cerebral palsy caused by different diseases. This has facilitated rebuilding of some of its neurological function. In this study, 80 such patients were followed up, including 20 patients with traumatic brain injury, 3...

Spinal capillary hemangioma: Report of five surgical cases and literature review

Liang Zhang, Zhifeng Zhang, Jifeng Shang, Wenqing Jia, Jun Yang, Yulun Xu

2017, 3(4): 196-203. doi:10.18679/CN11-6030/R.2017.029

Abstract ( 594 )

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Objective: Capillary hemangioma is a benign vascular malformation that is usually encountered in soft-tissue. Rarely, it may occur in the neuraxis, and spinal capillary hemangioma (SCH) is a rare variant of it. Existing literature on SCH is limited because of its rarity. As a result, epidemiological and clinical characteristics as well as management strategy for SCH are still lacking. Here, we present a report on five patients with pathologically proven SCH, treated in Beijing T...

Surgical treatment of congenital basilar invagination with different pathological characteristics: Report of 139 cases

Yinqian Wang, Tao Fan, Xingang Zhao, Cong Liang, Qifei Gai, Haijun Zhao

2017, 3(4): 204-212. doi:10.18679/CN11-6030/R.2017.030

Abstract ( 574 )

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Objective: To describe the different pathological characteristics of congenital basilar invaginations and discuss the surgical treatment of such cases.
Methods: A total of 139 patients diagnosed with basilar invaginations underwent surgical treatment from 2008 to 2015. Based on Atul Goel's classification and simultaneous consideration of atlantoaxial dislocation or syringomyelia, the cases were subdivided into four groups. Individualized posterior surgical ...

Effects of degenerative autologous nucleus pulposus on the lumbar sympathetic trunk: Sympathetic inflammation in rats

Yuanzhang Tang, Jingjing Bian, Yuna Guo, Chenli Sun, Yawei, Xiuhua Li, Jiaxiang Ni

2017, 3(4): 213-219. doi:10.18679/CN11-6030/R.2017.031

Abstract ( 472 )

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Objective: We have reported the presence of discogenic visceral pain secondary to anterior herniation of the lumbar disc. The aim of this study was to observe the inflammatory response of the sympathetic trunk to an autologous degenerative nucleus pulposus (NP) injection under fluoroscopy.
Methods: A total of 72 rats were used. In 24 rats, the autologous NP suspension was injected into the right sympathetic trunk. Next, food intake and body weight of each r...

Calcified chronic subdural hematoma: A case report and literature review

Zongyu Xiao, Xiaojuan Chen, Kunzheng Li, Zhengping Zhang

2017, 3(4): 220-223. doi:10.18679/CN11-6030/R.2017.032

Abstract ( 459 )

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Calcified chronic subdural hematoma (CCSDH) is a rare disease that accounts for approximately 0.3%-2.7% of all chronic subdural hematomas (CSDHs). The clinical features of CCSDH are very similar to those of noncalcified CSDH and include headache, decreased alertness, weakness, numbness, gait disturbance, seizures, memory impairment, confusion, and unconsciousness. All symptomatic CCSDH should be treated surgically. Majority of these patients recover well following surgery. In this report, we pre...

Neuronavigation combined with nerve electrophysiology in excision of brain abscess: A case report and literature review

Xiaoxu Shen, Dong Zhao, Qi Liu

2017, 3(4): 224-228. doi:10.18679/CN11-6030/R.2017.033

Abstract ( 511 )

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A brain abscess is a parenchymal infection, which is a severe intracranial infectious disease. Although the incidence is low, it causes serious inflammation and neurological deficits. The current treatments for brain abscesses are primarily surgical, including abscess resection or puncture and drainage. In recent years, extensive application of neuronavigation and electrophysiological monitoring technology have improved the safety and reliability of neurosurgery. To explore the application and c...

Hemodynamic consideration of intracranial aneurysm

Hiroshi Ujiie, Chie Shinohara, Yoshinori Tamano, Kouichi Katou, Akira Teramoto

2017, 3(4): 229-236. doi:10.18679/CN11-6030/R.2017.034

Abstract ( 462 )

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We reviewed basic considerations in fluid dynamics of cerebral aneurysms and applied these in surgery on the three most common types: internal carotid-posterior communicating artery, middle cerebral artery, and anterior communicating artery. It was found that aneurysmal initiation and growth do not occur at symmetric bifurcations. As blood flow always obeys the law of inertia, jet flow into the aneurysm will disperse along the wall; assuming the aneurysmal wall strength is even, the shape of the...

Review of insulin-like growth factor 1 signaling pathway and its role in protection against brain diseases

Min Wei, Lun Dong, Hengzhu Zhang, Zhenfei Teng, Xiaodong Wang, Zhengcun Yan, Lei She, Yuping Li, Xingdong Wang

2017, 3(4): 237-245. doi:10.18679/CN11-6030/R.2017.035

Abstract ( 484 )

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Insulin-like growth factor 1 (IGF-1) is a pluripotent growth factor, with multiple functions in the peripheral and central nervous systems. Increasing evidence suggests that IGF-1 fine-tunes the development of the central nervous system, ensuring proper neuronal differentiation, maturation, and connectivity. It supports neuronal survival and axon growth, and acts on myelinating Schwann cells and oligodendroglia. The biological functions of IGF-1 are modulated by the IGF-1 signaling pathway. Rece...

Neural matrix and its role in preoperative evaluation of partial epilepsy

Jingzhan Wu, Mingming Zhou

2017, 3(4): 246-256. doi:10.18679/CN11-6030/R.2017.036

Abstract ( 500 )

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The network characteristic of the central neural system has been widely accepted as a basic fabric form. However, the matrix characteristics of neural network are still not fully understood. If we ignore the matrix characteristics of the neural networks and just pay close attention to its connection mode, we are likely to fall into the theory of mechanical reductionism. This can lead to a problem in representing consciousness in a disadvantageous situation. It can also be a barrier to further im...

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