Clinical features and prognostic factors of primary intracranial malignant fibrous histiocytoma: A report of 8 cases and a literature review

doi:10.18679/CN11-6030/R.2016.024

Translational Neuroscience and Clinics

2016, Vol. 2

Issue (3): 155-164 doi: 10.18679/CN11-6030/R.2016.024

Original Articles

Clinical features and prognostic factors of primary intracranial malignant fibrous histiocytoma: A report of 8 cases and a literature review

Peng Li¹, Qiangyi Zhou¹, Zhijun Yang¹, Zhenmin Wang¹, Shiwei Li¹, Xingchao Wang¹, Bo Wang¹, Fu Zhao², Pinan Liu^1,2

1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
2 Department of Neural Reconstruction, Beijing Neurosurgery Institute, Capital Medical University, Beijing 100050, China

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Abstract Objective: Primary intracranial malignant fibrous histiocytoma (MFH) is rare. We describe the detailed clinical features of 8 cases and fully review the literature to evaluate several prognostic factors. Methods: Eight patients with pathologically confirmed primary intracranial MFH were retrospectively reviewed. We searched PubMed for relevant articles with the term "intracranial malignant fibrous histiocytoma". Results: Of the 8 patients, 4 were men and 4 were women. Three patients had received previous radiotherapy. The age of the patients ranged from 19 to 69 years, with a median age of 48 years. Most tumors could be totally resected; and only 1 tumor was subtotally resected. Six patients received postoperative radiotherapy and 3 patients received postoperative chemotherapy. Most patients died within the first year after surgery; and only 1 patient was still alive on the date of the last follow-up. We reviewed the literature and included a total of 46 patients in the Kaplan-Meier survival analysis. Young patients (less than 30 years old) seemed to have a better prognosis and survival rate than older patients (more than 30 years old) (log-rank test, P=0.008). However, sex (P=0.675), extent of resection (P=0.934), postoperative radiotherapy (P=0.592), and postoperative chemotherapy (P=0.424) did not affect patient prognosis. Conclusions: The prognosis of MFH is usually poor, and most patients die within the first year after surgery. Younger MFH patients (less than 30 years old) seem to have a better prognosis and improved survival compared to older patients.

Key words： clinical features prognostic factors intracranial malignant fibrous histiocytoma literature review

Received: 10 July 2016 Published: 30 September 2016

Corresponding Authors: Pinan Liu, E-mail:pinanliu@ccmu.edu.cn E-mail: pinanliu@ccmu.edu.cn


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	Peng Li
	Qiangyi Zhou
	Zhijun Yang
	Zhenmin Wang
	Shiwei Li
	Xingchao Wang
	Bo Wang
	Fu Zhao
	Pinan Liu

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Peng Li, Qiangyi Zhou, Zhijun Yang, Zhenmin Wang, Shiwei Li, Xingchao Wang, Bo Wang, Fu Zhao, Pinan Liu. Clinical features and prognostic factors of primary intracranial malignant fibrous histiocytoma: A report of 8 cases and a literature review. Translational Neuroscience and Clinics, 2016, 2(3): 155-164.

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http://tnc.tsinghuajournals.com/10.18679/CN11-6030/R.2016.024 OR http://tnc.tsinghuajournals.com/Y2016/V2/I3/155


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