Translational Neuroscience and Clinics

Development of skull base neurosurgery: From the past to the future

Pinan Liu

2016, 2(3): 153-154. doi:10.18679/CN11-6030/R.2016.029

Abstract ( 576 )

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The origin of neurosurgery dates back to the end of the 19th century. Many prominent and pioneering neurosurgeons contributed substantially to the development of skull base neurosurgery. In the naked eye era, Harvey Cushing promoted the delicate and meticulous surgical techniques, and significantly decreased the surgical mortality. In the 1960s, the operative microscope was introduced to the neurosurgery. Neurosurgeons represented by Yasargil took full advantage of this technology and pushed sku...

Clinical features and prognostic factors of primary intracranial malignant fibrous histiocytoma: A report of 8 cases and a literature review

Peng Li, Qiangyi Zhou, Zhijun Yang, Zhenmin Wang, Shiwei Li, Xingchao Wang, Bo Wang, Fu Zhao, Pinan Liu

2016, 2(3): 155-164. doi:10.18679/CN11-6030/R.2016.024

Abstract ( 565 )

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Objective: Primary intracranial malignant fibrous histiocytoma (MFH) is rare. We describe the detailed clinical features of 8 cases and fully review the literature to evaluate several prognostic factors. Methods: Eight patients with pathologically confirmed primary intracranial MFH were retrospectively reviewed. We searched PubMed for relevant articles with the term "intracranial malignant fibrous histiocytoma". Results: Of the 8 patie...

Gangliocytoma combined with a pituitary adenoma: Reports of three cases and literature review

Zhenmin Wang, Peng Li, Qiangyi Zhou, Zhijun Yang, Pinan Liu

2016, 2(3): 165-171. doi:10.18679/CN11-6030/R.2016.026

Abstract ( 383 )

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Objectives: Sellar gangliocytomas are extremely rare. Since they present clinically and radiologically as pituitary adenomas, the preoperative diagnosis of these mixed tumors is very difficult. Here, we report three cases of gangliocytoma combined with pituitary adenoma and describe our findings. Methods: The clinical data of the three cases of gangliocytoma combined with pituitary adenoma have been retrospectively analyzed, and the published literature has also...

Effects of voluntary imipramine intake via food and water in paradigms of anxiety and depression in naïve mice

João Pedro Costa-Nunes, Anastassia Bakhmet, Margarida Araújo-Correia, Andreia Barbosa Valença, Tatyana Strekalova, Harry W. M. Steinbusch

2016, 2(3): 172-182. doi:10.18679/CN11-6030/R.2016.021

Abstract ( 430 )

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Objective: We sought to investigate the efficacy of oral dosing in mice with imipramine (7mg/kg/day) via water or in food pellets, and to compare its effects in the paradigms of learned helplessness, locomotion, hedonic state, and anxiety. Methods: Water and food consumption were measured to determine daily imipramine dosage in C57BL/6N mice. Next, baseline scores for O-maze, dark/light box, and sucrose tests were measured. Mice were then subjected to a 4-week t...

Comparison of different microsurgery methods for trigeminal neuralgia

Zihang Xie, Lin Chen, Yan Wang, Zhiqiang Cui, Shijie Wang, Qiang Ao, Yuqi Zhang, Huancong Zuo

2016, 2(3): 183-187. doi:10.18679/CN11-6030/R.2016.022

Abstract ( 423 )

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Objective: To study the influence of different microsurgical methods on surgical outcomes and complications, and to improve the surgical outcomes for trigeminal neuralgia. Methods: The clinical data of 109 patients with trigeminal neuralgia, who were treated with microsurgery, were analyzed retrospectively. All patients were divided into 3 groups according to surgical modality: the trigeminal neuralgia decompression group (TND group, 19 patients), the TND and rh...

Post-traumatic cerebrospinal fluid rhinorrhea associated with craniofacial fibrous dysplasia: Case report and literature review

Peng Li, Qiangyi Zhou, Zhijun Yang, Zhenmin Wang, Shiwei Li, Xingchao Wang, Bo Wang, Fu Zhao, Pinan Liu

2016, 2(3): 188-194. doi:10.18679/CN11-6030/R.2016.025

Abstract ( 637 )

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Objective: Fibrous dysplasia (FD) is an unusual developmental abnormality of the skeleton. When facial and cranial bones are involved in FD, it is termed craniofacial fibrous dysplasia (CFD). Although several reports have reported that CFD has a tendency for spontaneous cerebrospinal fluid (CSF) leakage, there have been no related English-language case reports. We present the first case of post-traumatic CSF rhinorrhea associated with CFD. Methods: A 30-year-old...

Subarachnoid hemorrhage after surgery of the medulla oblongata hemangioblastoma: A case report

Xiang Yang, Yuekang Zhang, Xuesong Liu, Maojun Chen

2016, 2(3): 195-198. doi:10.18679/CN11-6030/R.2016.027

Abstract ( 477 )

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Objectives: To discuss the bleeding mechanisms after removing a medulla oblongata hemangioblastoma. Methods: A 42-year-old male patient was diagnosed with a medulla oblongata hemangioblastoma. Preoperative cranial magnetic resonance imaging, computed tomography angiography and post-surgery computed tomography were completed during clinical procedure. We also reviewed the related literatures. Results: The preoperative computed tomography angiogra...

Complete resection of cavernous malformations in the hypothalamus: A case report and review of the literature

Xingchao Wang, Zhenmin Wang, Zhixian Gao, Pinan Liu

2016, 2(3): 199-202. doi:10.18679/CN11-6030/R.2016.028

Abstract ( 487 )

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Objective: Cavernous malformation (CM) originating from the hypothalamus is extremely rare and the deep location presents a challenge for its neurosurgical management. We report such a case to better understand its clinical features. Methods and Results: A 40-year-old male patient presented with impaired vision in the left eye. Magnetic resonance imaging (MRI) revealed a regularly shaped round lesion located in the suprasellar cistern, and a clinical diagnosis o...

Global action against dementia: Emerging of a new era

Dajue Wang

2016, 2(3): 203-209. doi:10.18679/CN11-6030/R.2016.023

Abstract ( 309 )

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Since ancient times medical profession has typically dealt with physical disorders, because they are visible, palpable, and audible. The diagnosis is relatively direct. Mental health problems are hidden in the brain and we did not know what was going on inside the skull. We could only infer, by observing the patient's behaviors and making assumptions. Even now, we have to largely rely on this indirect approach. That is why psychology and psychiatry are classified as behavioral sciences. They are...

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