Please wait a minute...
Translational Neuroscience and Clinics  2016, Vol. 2 Issue (3): 199-202    doi: 10.18679/CN11-6030/R.2016.028
Short Communications     
Complete resection of cavernous malformations in the hypothalamus: A case report and review of the literature
Xingchao Wang1, Zhenmin Wang1, Zhixian Gao1, Pinan Liu1,2
1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
2 Department of Neural Reconstruction, Beijing Neurosurgery Institute, Capital Medical University, Beijing 100050, China
Download: PDF (2081 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  Objective: Cavernous malformation (CM) originating from the hypothalamus is extremely rare and the deep location presents a challenge for its neurosurgical management. We report such a case to better understand its clinical features. Methods and Results: A 40-year-old male patient presented with impaired vision in the left eye. Magnetic resonance imaging (MRI) revealed a regularly shaped round lesion located in the suprasellar cistern, and a clinical diagnosis of hypothalamic CM was made. Complete microsurgical excision was performed via a right pterional craniotomy. The patient showed good recovery with no further visual acuity or field deficits postoperatively. No CM recurrence or rebleeding was seen on follow-up MRI scans performed over the course of two years. Conclusions: For patients with cavernous malformation in the hypothalamus, accurate preoperative diagnosis with complete surgical removal by an appropriate surgical approach can contribute to satisfactory outcomes.

Key wordscavernous malformation      deep-location      hypothalamus      surgery     
Received: 05 July 2016      Published: 30 September 2016
Corresponding Authors: Pinan Liu, E-mail:pinanliu@ccmu.edu.cn;Zhixian Gao, E-mail:elunlun0555@sina.com     E-mail: pinanliu@ccmu.edu.cn;elunlun0555@sina.com
Cite this article:

Xingchao Wang, Zhenmin Wang, Zhixian Gao, Pinan Liu. Complete resection of cavernous malformations in the hypothalamus: A case report and review of the literature. Translational Neuroscience and Clinics, 2016, 2(3): 199-202.

URL:

http://tnc.tsinghuajournals.com/10.18679/CN11-6030/R.2016.028     OR     http://tnc.tsinghuajournals.com/Y2016/V2/I3/199

 
 
 
[1]   Batra S, Lin D, Recinos PF, Zhang J, Rigamonti D. Cavernous malformations:Natural history, diagnosis and treatment. Nat Rev Neurol 2009, 5(12):659-670.<br />
[2]   Hassler W, Zentner J, Wilhelm H. Cavernous angiomas of the anterior visual pathways. J Clin Neuroophthalmol 1989, 9(3):160-164.<br />
[3]   Mizutani T, Goldberg HI, Kerson LA, Murtagh F. Cavernous hemangioma in the diencephalon. Arch Neurol 1981, 38(6):379-382.<br />
[4]   Reyns N, Assaker R, Louis E, Lejeune JP. Intraventricular cavernomas:Three cases and review of the literature. Neurosurgery 1999, 44(3):648-654.<br />
[5]   Samii M, Eghbal R, Carvalho GA, Matthies C. Surgical management of brainstem cavernomas. J Neurosurg 2001, 95(5):825-832.<br />
[6]   Abou-Al-Shaar H, Bahatheq A, Takroni R, Al-Thubaiti I. Optic chiasmal cavernous angioma:A rare suprasellar vascular malformation. Surg Neurol Int 2016, 7(Suppl 18):S523-S526.<br />
[7]   Liu JK, Lu Y, Raslan AM, Gultekin SH, Delashaw JB Jr. Cavernous malformations of the optic pathway and hy-pothalamus:Analysis of 65 cases in the literature. Neurosurg Focus 2010, 29(3):E17.<br />
[8]   Mizoi K, Yoshimoto T, Suzuki J. Clinical analysis of ten cases with surgically treated brain stem cavernous angiomas. Tohoku J Exp Med 1992, 166(2):259-267.<br />
[9]   Kurokawa Y, Abiko S, Ikeda N, Ideguchi M, Okamura T. Surgical strategy for cavernous angioma in hypothalamus. J Clin Neurosci 2001, 8 Suppl1:106-108.<br />
[10]   Katayama Y, Tsubokawa T, Maeda T, Yamamoto T. Surgical management of cavernous malformations of the third ventricle. J Neurosurg 1994, 80(1):64-72.<br />
[11]   Rheinboldt M, Blase J. Exophytic hypothalamic cavernous malformation mimicking an extra-axial suprasellar mass. Emerg Radiol 2011, 18(4):363-367.<br />
[12]   Gross BA, Du R. Cerebral cavernous malformations:Natural history and clinical management. Expert Rev Neurother 2015, 15(7):771-777.<br />
[13]   Simard JM, Garcia-Bengochea F, Ballinger WE Jr, Mickle JP, Quisling RG. Cavernous angioma:A review of 126 collected and 12 new clinical cases. Neurosurgery 1986, 18(2):162-172.<br />
[14]   Hempelmann RG, Mater E, Schröder F, Schön R. Complete resection of a cavernous haemangioma of the optic nerve, the chiasm, and the optic tract. Acta Neurochir (Wien) 2007, 149(7):699-703; discussion 703.<br />
[15]   Wang CH, Lin SM, Chen Y, Tseng SH. Multiple deep-seated cavernomas in the third ventricle, hypothalamus and thalamus. Acta Neurochir (Wien) 2003, 145(6):505-508.<br />
[16]   Ogawa Y, Tominaga T. Sellar and parasellar tumor removal without discontinuing antithrombotic therapy. J Neurosurg 2015, 123(3):794-798.<br />
[17]   Hasegawa H, Bitoh S, Koshino K, Obashi J, Kobayashi Y, Kobayashi M, Wakasugi C. Mixed cavernous angioma and glioma (angioglioma) in the hypothalamus-Case report. Neurol Med Chir (Tokyo) 1995, 35(4):238-242.<br />
[18]   Robinson JR, Awad IA, Little JR. Natural history of the cavernous angioma. J Neurosurg 1991, 75(5):709-714.<br />
[19]   Porter RW, Detwiler PW, Spetzler RF, Lawton MT, Baskin JJ, Derksen PT, Zabramski JM. Cavernous malformations of the brainstem:Experience with 100 patients. J Neurosurg 1999, 90(1):50-58.<br />
[20]   Lehner M, Fellner FA, Wurm G. Cavernous haemangiomas of the anterior visual pathways. Short review on occasion of an exceptional case. Acta Neurochir (Wien) 2006, 148(5):571-578.
[1] Wenbin Ding, Shaocheng Zhang, Zhuo Wang, Lin Chen, Chuansen Zhang, Ping Huang, Shunfa Liu, Laiqing Sun, Yuhai Ma, Jun Yang, Fei Huang, Chengjing Xue, Yanxue Zhong, Lei Yin, Yongtai Pan, Dajiang Wu. Using nerve segment insert grafting to reconstruct neural pathways of brain-derived paralysis[J]. Translational Neuroscience and Clinics, 2017, 3(4): 188-195.
[2] James Wang. Neurospinal surgery innovations[J]. Translational Neuroscience and Clinics, 2017, 3(3): 121-122.
[3] Zhenxing Sun, Dan Yuan, Yaxing Sun, Zhanquan Zhang, James Wang, Yi Guo, Guoqin Wang, Dongkang Liu, Peng Chen, Linkai Jing, Feng Yang, Peihai Zhang, Huifang Zhang, Youtu Wu, Wei Shi, Guihuai Wang. Fluorescein sodium use during spinal ependymoma resection[J]. Translational Neuroscience and Clinics, 2017, 3(3): 123-134.
[4] Wen Yin, Jianrong Ma, Yiwei Liao. Surgical treatment of brainstem cavernous malformations with three basic skull base approaches and minimally invasive techniques:Observations in 20 patients[J]. Translational Neuroscience and Clinics, 2017, 3(2): 74-83.
[5] Jiefei Li, Yuqi Zhang, Huancong Zuo. Cerebral glioblastoma mimicking a cavernous malformation: A case report and literature review[J]. Translational Neuroscience and Clinics, 2017, 3(1): 35-39.
[6] Chengwei Xu, Wenjing Zhou. Stereoelectroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) in patients with drug-resistant focal epilepsy[J]. Translational Neuroscience and Clinics, 2017, 3(1): 40-47.
[7] Zihang Xie, Lin Chen, Yan Wang, Zhiqiang Cui, Shijie Wang, Qiang Ao, Yuqi Zhang, Huancong Zuo. Comparison of different microsurgery methods for trigeminal neuralgia[J]. Translational Neuroscience and Clinics, 2016, 2(3): 183-187.
[8] Pinan Liu. Development of skull base neurosurgery: From the past to the future[J]. Translational Neuroscience and Clinics, 2016, 2(3): 153-154.
[9] Yapeng Zhao, Hongyu Duan, Qinghui Zhang, Bingxin Shi, Hui Liang, Yuqi Zhang. Malignant transformation and treatment of cystic mixed germ cell tumor[J]. Translational Neuroscience and Clinics, 2016, 2(1): 25-30.