Translational Neuroscience and Clinics

Quantum correlated imaging is a promising new technique in medical imaging

Nan Zhang, Zhaohua Yang

2017, 3(2): 63-65. doi:10.18679/CN11-6030/R.2017.014

Abstract ( 415 )

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Cardio-cerebral vascular diseases are common and frequently occurring serious diseases that threaten humans.In recent years,Digital Subtraction Angiography (DSA) has played a vital role in the diagnosis and treatment of cardio-cerebral vascular diseases.However,DSA is not able to visualize intravascular structures in real time,and it is especially difficult to evaluate each layer of the vascular wall and the composition of atherosclerotic plaques with DSA.Quantum correlated imaging is a new tech...

Differences in the prognostic value of tumor extent of resection among the molecular subgroups of medulloblastoma:A single centre study of 113 cases

Yuyuan Wang, Kay Kawai Li, Ji Xiong, Zhenyu Zhang, Yang Wang, Jian Xu, Yin Wang, Hokeung Ng, Ping Zhong

2017, 3(2): 66-73. doi:10.18679/CN11-6030/R.2017.015

Abstract ( 464 )

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Medulloblastoma (MB) is one of the most common pediatrics malignant tumors of the central nervous system.Studies in America and Europe have demonstrated significant differences in the prognostic value of medulloblastoma extent among molecular subgroups of medulloblastoma.However,studies focusing on the Chinese population are still lacking.A total of 113 patients with medulloblastoma who underwent surgical resection in Huashan Hospital between January 2002 and December 2013 were included in this ...

Surgical treatment of brainstem cavernous malformations with three basic skull base approaches and minimally invasive techniques:Observations in 20 patients

Wen Yin, Jianrong Ma, Yiwei Liao

2017, 3(2): 74-83. doi:10.18679/CN11-6030/R.2017.019

Abstract ( 677 )

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Objective: Brainstem cavernous malformation (BSCM) is extremely challenging for neurosurgeons in terms of surgical approach choices.In this article,we summarized our experience in skull base approaches of BSCM,and elucidated the advance of surgical treatments of brain stem cavernous malformation through reviewing recent relevant articles.
Methods: We retrospectively reviewed 20 consecutive patients who underwent resection between May 1,2014 and April 30,201...

Multiple factor analysis of symptomatic intracranial arterial stenosis

Chuanqiang Qu, Yuanyuan Zhao, Qinjian Sun, Yifeng Du

2017, 3(2): 84-89. doi:10.18679/CN11-6030/R.2017.011

Abstract ( 441 )

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Objective: To discuss the correlation among intracranial arterial stenosis and its risk factors.
Methods: A total of 486 patients with transient ischemic attack (TIA) or ischemic cerebral infarction were examined using color doppler flow imaging (CDFI) and transcranial doppler ultrosonography (TCD).According to the degrees of extracranial arterial stenosis,patients with mild-to-moderate extracranial stenosis were classified into group A (435 cases) while th...

Severe remote cerebellar hemorrhage with intracerebral hemorrhage after burr-hole evacuation for chronic subdural hematoma

Hua Yu, Song Tong, Ahmed Abdelmaksoud, Fu Peng, Huang Tao, Yizhi Huang, Weichao Liu, Yuan Ye, Raya A. Almaraihah, Nanxiang Xiong

2017, 3(2): 90-96. doi:10.18679/CN11-6030/R.2017.010

Abstract ( 403 )

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Since remote cerebellar hemorrhage,with intracerebral hemorrhage after supratentorial neurosurgery,is rare,its pathophysiology remains elusive.Here,we report a 64-year-old man who had severe bilateral symmetric remote cerebellar hemorrhage with frontal lobe hemorrhage following burr-hole evacuation for supratentorial chronic subdural hematoma.Computed tomography venography showed undeveloped left internal jugular vein and sigmoid sinus.He received 3 weeks of conservative treatment and fully reco...

Is the role of the angiotensin-converting enzyme gene in Alzheimer's disease independent of hypertension?

Yuanhan Yang, Shyhjong Wu, Chinchun Huang, Jongling Fuh, Chingkuan Liu

2017, 3(2): 97-103. doi:10.18679/CN11-6030/R.2017.013

Abstract ( 351 )

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Objective: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms are considered biomarkers of late-onset Alzheimer's disease (AD).However,the results of studies of these polymorphisms have been inconsistent.The ACE protein directly degrades beta-amyloid and thereby slows the progression of AD and its onset.However,it also activates the renin-angiotensin-aldosterone system,which can contribute to hypertension and/or cardiovascular events that increase the ris...

Generation of genetically modified olfactory ensheathing cells that secrete VEGF:Potential application in cell-based treatment of leukoaraiosis

Chuanqiang Qu, Yuanyuan Zhao, Qinjian Sun, Yifeng Du

2017, 3(2): 104-110. doi:10.18679/CN11-6030/R.2017.012

Abstract ( 590 )

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Objective: We aimed to provide an alternative cell source for cell therapy in leukoaraiosis (LA).
Methods: Olfactory ensheathing cells (OECs) from the olfactory bulb were isolated,cultured,and purified.Next,the lentivirus carrying human VEGF165 gene was constructed and transfected into OECs.
Results: The proliferative capacity of primary OECs was strong.OECs were infected with different multiplicity of infection.The expression level of...

Intrasellar cavernous hemangioma:A case report and literature review

Xinmin Wu, Hongquan Yu, Gang Zhao, Le Wang, Yang Liu, Yunqian Li

2017, 3(2): 111-115. doi:10.18679/CN11-6030/R.2017.018

Abstract ( 382 )

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Intrasellar cavernous hemangioma is rare.There are no specific symptoms and the mass effect often mimics pituitary macroadenoma.We present one case of intrasellar cavernous hemangioma that was misdiagnosed.Progressively decreasing vision was the main symptom in this case.The prolactin level was mildly increased but other biochemistry examinations were normal.Magnetic resonance imaging showed an enlarged pituitary fossa and an irregular solid tumor (33 mm×22 mm×22 mm) in the sella tur...

Ghost imaging for online angiography

Zhaohua Yang, Nan Zhang, Yuzhe Sun, Yuanjin Yu

2017, 3(2): 116-120. doi:10.18679/CN11-6030/R.2017.016

Abstract ( 500 )

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Ghost imaging (GI) has characteristics that make it promising for applications in life sciences and other fields,such as its high sensitivity and strong anti-interference compared with traditional imaging.This paper presents a new approach for online angiography using GI.Two signals are correlation-calculated to detect the object image:one of them is the random light field generated by a computer,and the other enters the optical fiber path after being transmitted to the detected object via a mod...

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