Progress in the research and development of nerve conduits
Xiyuan Wang1, Lin Chen2, Qiang Ao1, Aruna Sharma3, Hari Shanker Sharma3
1 Department of Tissue Engineering, China Medical University, Shen Yang 110122, China;
2 Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100040, China;
3 Laboratory of Cerebrovascular Research, Department of Surgical Sciences Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Sweden
Progress in the research and development of nerve conduits
Xiyuan Wang1, Lin Chen2, Qiang Ao1, Aruna Sharma3, Hari Shanker Sharma3
1 Department of Tissue Engineering, China Medical University, Shen Yang 110122, China;
2 Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100040, China;
3 Laboratory of Cerebrovascular Research, Department of Surgical Sciences Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Sweden
摘要 The reconstruction after peripheral nerve damage, especially for long-segment nerve defects, remains a clinical challenge. Autologous nerve graft transplantation is an efficient method for the repair of peripheral nerve defects, but the involved complications and shortcomings have greatly limited the clinical efficacy of treatments offered to patients with nerve defects. Thus, there is an urgent need to develop new therapeutic strategies and explore alternatives to autologous nerve transplantation in clinical practice, based on the knowledge of the peripheral nerve regeneration mechanism and biological histocompatibility principles. With significant advances in the research and application of nerve conduits, they have been used to repair peripheral nerve injury for several decades. In this paper, the study background of nerve conduits, their applications in clinic, status of conduit material research and construction of tissue-engineered artificial nerves were reviewed.
Abstract: The reconstruction after peripheral nerve damage, especially for long-segment nerve defects, remains a clinical challenge. Autologous nerve graft transplantation is an efficient method for the repair of peripheral nerve defects, but the involved complications and shortcomings have greatly limited the clinical efficacy of treatments offered to patients with nerve defects. Thus, there is an urgent need to develop new therapeutic strategies and explore alternatives to autologous nerve transplantation in clinical practice, based on the knowledge of the peripheral nerve regeneration mechanism and biological histocompatibility principles. With significant advances in the research and application of nerve conduits, they have been used to repair peripheral nerve injury for several decades. In this paper, the study background of nerve conduits, their applications in clinic, status of conduit material research and construction of tissue-engineered artificial nerves were reviewed.
Xiyuan Wang, Lin Chen, Qiang Ao, Aruna Sharma, Hari Shanker Sharma. Progress in the research and development of nerve conduits[J]. 临床转化神经科学, 2015, 1(2): 97-101.
Xiyuan Wang, Lin Chen, Qiang Ao, Aruna Sharma, Hari Shanker Sharma. Progress in the research and development of nerve conduits. Translational Neuroscience and Clinics, 2015, 1(2): 97-101.
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2015, Vol. 1 
